Describe and explain the physiologic basis of the common complications of infectious mononucleosis. Infectious mononucleosis is spread through the saliva oropharyngeal route. After the fever is gone, the virus is still carried in the saliva for up to 6 months, but in small amounts. Infectious mononucleosis im is a widely spread systemic viral disease caused in 90% of cases by the epsteinbarr virus evb and approximately 95% of the adult population is ebvseropositive. Mononucleosis the student health provider has diagnosed mononucleosis, also known as mono. The hybridoma was expanded to get soluble e1d1 protein. Often affectionately called medpeds, it is a shortened term for combined internal. Pierremont pediatrics pediatricans shreveport bossier city. Peripheral blood lymphocytes express recombination activating. Mononucleosis also known as mono or the kissing disease is a viral infection most commonly caused by the epsteinbarr virus ebv. It is characterized by fever, sore throat, and enlarged lymph nodes, and may include headache, fatigue, andor puffy eyelids. Complete blood count cbc may be done to help confirm the diagnosis of mono and rule out other infections or complications of mono. It can be caused by a number of pathogens, but this. Infectious mononucleosis, a systemic illness caused by the epsteinbarr virus, is seen frequently by primary care physicians.
Teens and young adults are most likely to catch it. Infectious mononucleosis mono, ebv mononucleosis fact. Mononucleosis and sports participation the healthy md. Sore throat is probably the most common symptom of mono. Many people who get mono do not even know they have it. Aug 19, 2010 mononucleosis sometimes called mono, the kissing disease, or glandular fever is a viral infection transmitted through saliva. It is most often caused by infection with the epsteinbarr virus ebv. Infectious mononucleosis is either caused by the epsteinbarr virus ebv or the cytomegalovirus, both of whom are members of the herpes simplex virus family. Ebv is estimated to have infected over 90% of people aged 40 and.
Infectious mononucleosis mono, ebv mononucleosis fact sheet. Apply online for home health lvnlpn nursing jobs at aveanna healthcare providing revolutionary behavioral health services to children and their families. Perinatal and clinical genetics, department of pediatrics. We report the case of a 23monthold female who developed ebvassociated diffuse large bcell. An eight year old white boy developed meningeal signs, intermittent coma, opisthotonos, extensor spasms, mild papilledema and hyperpyrexia two weeks after the onset of a sore throat and cervical lymphadenopathy. The common symptoms of mononucleosis include fever, sore throat, swollen lymph nodes, and fatigue. Infectious mononucleosis was first described by sprunt and evans in the bulletin of the johns hopkins hospital in 1920. Mononucleosis mono is an infectious disease caused most often by the epsteinbarr virus ebv. It is caused by the epstein barr virus ebv which is a herpesvirus. Infectious mononucleosis encephalitis american academy of. Inside lsu health shreveport is published three times.
Nick gagliano professorship in emergency pediatrics total. Mononucleosis mononucleosis is often referred to as mono or the kissing disease. Infectious mononucleosis, or mono, is caused by the epsteinbarr virus, which is transmitted in infected saliva by coughing, sneezing, and kissing. Louisiana state university health sciences center shreveport 9. Mononucleosis infecciosa infectious mononucleosis dra. Infectious mononucleosis is a viral disease that affects certain blood cells. Enhanced systemic bioavailability of curcumin through. Internal medicine pediatrics lsu health shreveport. Epsteinbarr virus infectious mononucleosis american family. Ebv has been associated to malignancy in patients with immunodeficiency. Mononucleosis tests including the monospot test and ebv antibody test are blood tests.
It is spread by intimate contact between susceptible persons and people shedding the eb virus. Primary infection by epsteinbarr virus ebv typically presents with all the main features of mononucleosis. In rare causes of mononucleosis, there can be airway compromise due to pharyngeal or tonsillar swelling, cardiac complications, or enlargement of the spleen. Overall, mononucleosis is only slightly contagious from contacts.
We present 42 cases of infectious mononucleosis caused by the epsteinbarr virus in children. One of the many things you need to do to prepare for your little ones arrival is to choose a doctor to oversee their health care. Professor of medicine, pediatrics, and anesthesiology, and chief of the section of pediatric pulmonary medicine. There is no good scientific evidence to support mononucleosis as a cause of chronic fatigue syndrome. Although mononucleosis can occur at any age, it is most common in 15 to 25 yearolds, possibly because of their more intimate contacts. Publications from the american academy of pediatrics benefit from expertise and. Epidemiology it is estimated that 79% of infectious mononucleosis is caused by the epsteinbarr virus ebv, and the other 21% is caused by acute cmv infection see manual. Ebv is a herpesvirus and is related to herpes simplex virus. Mono is usually a mild illness that goes away without treatment after several weeks. The diagnosis of infectious mononucleosis was confirmed by a heterophile antibody titer of 1. It was initially described as drusenfieber or glandular fever in 1889, but the term infectious mononucleosis was later used in 1920 to describe six college students with a febrile illness characterized by absolute lymphocytosis and atypical mononuclear cells in. Article in spanish monso puigcercos g1, pou fernandez j, trujillo isern g, juncosa morros t, cambra lasaosa fj. Characteristically it consists of fever, lymphadenopaty and acute pharyingitis and ocasionally it will also present.
The symptoms of this syndrome include fatigue, weakness, recurrent pains, and the. Treatment with amoxicillin was associated with cutaneous rash. The occurrence of smooth muscle neoplasms and lymphoproliferative disorders in immunocompromised patients is well recognized. Antinuclear antibodies and anticytoplasmic antibodies in bronchial. It can be caused by a number of pathogens, but this chapter only discusses infectious mononucleos. She is also investigating the synergy of ebv with another tumor. Most adults in the united states have been exposed to the epsteinbarr virus, which is a very common virus. Mar 01, 2005 after completing this article, readers should be able to. Mononucleosis revised 10222004 mononucleosis is a viral illness characterized by fever, sore throat, swollen lymph nodes, and abnormalities in the white blood cells. Life at lsu health sciences center shreveport remains invigorating as each day. John vanchiere, professor of pediatrics and infectious disease at lsu health shreveport, stresses that now, more than ever, people should get a flu shot. Pediatrics louisiana state university health shreveport. Implicit in the persistence of epsteinbarr virus ebv in b lymphocytes is the. This virus is spread through saliva, and you may catch it from kissing or from sharing food or drinks.
Pierremont pediatrics in shreveport provides accessible, compassionate and quality healthcare for our patients. Consenso sobre infecciones en pediatria ambulatoria. Pediatric infectious mononucleosis childrens national. Infectious mononucleosis is a clinical entity characterized by sore throat, cervical lymph node enlargement, fatigue, and fever most often seen in adolescents and young adults and lasting several weeks. It is possible for the monospot test to come back negative early in the course of the infections false negative. Mononucleosis affects several organ systems, and, within the abdomen, there can be splenic involvement, hepatitis, mesenteric lymphadenopathy, hyperplasia of gutassociated lymphoid tissue, pancreatitis, and transient malabsorption. Barr virus ebv, which is a member of the herpesvirus family. Assembly and architecture of the ebv b cell entry triggering complex. Oct 01, 2004 infectious mononucleosis should be suspected in patients 10 to 30 years of age who present with sore throat and significant fatigue, palatal petechiae, posterior cervical or auricular adenopathy. Infectious mononucleosis is an acute viral infection that primarily affects lymph tissue. A case of severe encephalitis due to infectious mononucleosis is reported. Describe and explain the physiologic basis of the clinical features of infectious mononucleosis.
It is spread by intimate contact between susceptible persons and. Jan 21, 2020 mononucleosis mono is a common viral infection in high school and college students that can present with fever, body aches, fatigue, rash and respiratory symptoms. Infectious mononucleosis is a viral illness in most cases, and as such it can be treated with rest, hydration, analge sia, and antipyretics. Mononucleosis diagnostico y tratamiento mayo clinic. Infectious mononucleosis forest hills pediatric associates. Mono is an infection caused by a virus, not a bacteria. Infectious mononucleosis mono, ebv mononucleosis fact sheet what is infectious mononucleosis. But other organisms such as cytomegalovirus cmv may also trigger it. Epsteinbarr virus infectious mononucleosis american. Characteristically it consists of fever, lymphadenopaty and acute.
Welcome to the lsu health shreveport internal medicine pediatrics division. American academy of pediatrics recommends antiviral treat. Department of pediatrics, university of lubeck, lubeck. Neither of these findings means that mononucleosis has recurred. Although the symptoms of mononucleosis are uncomfortable, the infection resolves on its own without longterm effects. Many viral antigens are expressed during lytic infection. Abdominal complications of infectious mononucleosis. But in some cases it presents with few or atypical symptoms, making diagnosis more challenging. Epsteinbarr virus ebv persists lifelong in infected hosts despite the presence of antiviral immunity. Infectious mononucleosis is most contagious while your child has a fever. Infectious mononucleosis is a common, usually mild illness.
Any article or views expressed in this publication are. Abstract the infectious mononucleosis im etiology its attributed to several virus, mainly epsteinbarr virus ebv, discovered by epstein, achong and barr 36years ago. Epsteinbarr virus primary infection in healthy children. Infectious mononucleosis in adults and adolescents. Pediatric pulmonary epsteinbarr viruspositive diffuse large b.
Infectious mononucleosis im is characterized by a triad of fever, tonsillar pharyngitis, and lymphadenopathy. From the department of pediatrics, pulmonary allergy section. Epsteinbarr virus infections infectious mononucleosis. Mononucleosis is actually caused by viruses, just like a cold, but it can be more serious than other viral infections.
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